We aim to improve the detection and treatment of neuropsychiatric disorders by identifying cellular endophenotypes and their molecular correlates, in the context of genetic and environmental factors.

The Shen lab seeks to understand the complex interplay between genes and environment in neuropsychiatric disorders. We are particularly interested in the impact of early-life and cumulative exposures on later-life outcomes as related to mood disorders, psychosis, substance use, and neurodegeneration. We draw upon tools and perspectives from diverse fields, including systems biology, drug discovery, and environmental health sciences. Our current focus is on oxidative stress, a convergence point of cellular dysfunction across neurodevelopmental and neurodegenerative disorders. Using cellular and animal models, we are examining the combinatorial effects of genetic variants and environmental exposures (e.g., dietary antioxidants and smoking-related toxicants) on oxidative stress in brain cell types. By gaining a molecular understanding of exposures related to social determinants of health, we aim to bridge basic science and health services research to improve mental health outcomes.

We are affiliated with the following institutes: